Home / Juvenon Health Journal / Feeling Pain? Try DHA, EPA and Aspirin 8/06


Juvenon Health Journal Vol. 5 No. 8, August 2006

Research Update

The interaction of inflammation and pain has long been a complex scientific puzzle. Inflammation helps the body to heal wounds and repel toxic attacks. When health is restored, the enzymes that caused the inflammation are turned off. As scientists have explored inflammation over many decades, they have learned that many of the same enzymes and mechanisms are involved in turning inflammation both on and off. Recently discovered metabolites called resolvins play a critical role in this process, and understanding of their role has shed surprising new light on how one of the oldest pain-killers, aspirin, works. For detailsclick here.
“Controlling inflammation: a fat chance?”J. Exp. Med., Vol 201, No 5, March 7, 2005 671-674

This Research Update column highlights articles related to recent scientific inquiry into the process of human aging. It is not intended to promote any specific ingredient, regimen, or use and should not be construed as evidence of the safety, effectiveness, or intended uses of the Juvenon product. The Juvenon label should be consulted for intended uses and appropriate directions for use of the product.

Feeling Pain? Try DHA, EPA and Aspirin

By Benjamin V. Treadwell, Ph.D.

Certain fats, known as essential fats because our cells cannot synthesize them, are required to remain healthy. Two major categories of essential fats are the omega 6 and omega 3 fats. They are so labeled to designate the carbon atom where the most distal double bond is located (either the 6th or 3rd carbon in from the terminal carbon atom of the respective fatty acid). The omega 6 fatty acids are generally associated with promoting inflammation and pain, whereas the omega 3 fatty acids seem to be the nice guys who douse the fire and soothe the pain.

For maximum health we need both types, but as recent research is demonstrating, biological systems and pathways virtually always involve self-regulating events to maintain a delicate and healthy balance. Today’s article is about how we can help promote a healthy, pain-free balance through diet, and by taking a reasonably safe dietary supplement along with a modest amount of an old plant-derived analgesic.


Our human ancestors evolved in coastal areas and consumed large quantities of marine animals, as well as plants containing high levels of the omega 3 fatty acids. The estimated early human intake ratio of the omega 6 fatty acids to the omega 3 was approximately 1:1. In the modern western diet this ratio has deviated significantly, and is currently estimated to be as high as 20:1, skewed towards the inflammatory omega 6 fatty acids. Why? First, we eat a significant amount of meat from grain-fed animals, and due to putative advances in agriculture, the grain is low in the omega 3 and high in the omega 6 fats. Furthermore, the omega 3 fats are more susceptible to destruction by techniques used in processing various plants to make oils, such as vegetable oils. The consequence is a preponderance of the omega 6 fats in these oils. So, in effect we are consuming a pro-inflammatory diet. “We are what we eat” is painfully true with respect to the fats in our diet.

If the omega 6 fats are pro-inflammatory, why do we need them?

The omega 6 fats are converted into numerous important metabolic products, some of which function as signaling molecules to inform the cell of invasion by a toxic agent, such as a bacteria or virus. These molecules activate cells and mediators of the immune system, and cause subsequent inflammation (leaky blood vessels which promote redness and swelling), all for the purpose of eliminating the pathogen.

It appears that when these functionally very different molecules interact with certain enzymes and chemical receptors, they can twist them into either pro-inflammatory or anti-inflammatory units.

What stops this inflammatory process?

How does the tissue shut off the immune system once the pathogen is eliminated? The omega 3 fats activate the pathway leading to the resolution of the inflamed condition.

It is truly amazing that we survive as long as we do with so many complex mechanisms involved in maintaining our health. Research data, generated from a number of laboratories working together, reveal how one switch can activate two opposing pathways. It turns out that the same enzyme (COX-2), acting on an omega 6 fatty acid to produce inflammatory signaling molecules, can also act on omega 3 fatty acids to produce anti-inflammatory molecules. How is this possible? It appears that when these functionally very different molecules interact with certain enzymes and chemical receptors, they can twist them into either pro-inflammatory or anti-inflammatory units. Once the inflammation has reached some critical point, the omega 3 fatty acids become prominent and interact with the enzyme, COX-2, which converts the omega 3 fat to a metabolite that induces production of a newly discovered class of anti-inflammatory metabolites, the resolvins (for resolution of inflammation). The resolvin binds to a receptor, which in turn activates anti-inflammatory pathways. If all is in balance, the net result is the elimination of the pathogen and the return of the tissue from an inflamed war-zone condition to normal pain-free tissue.

Where does aspirin come into the story?

Unfortunately, as we all know, aches and pains don’t always disappear quickly after an infection or inflammation-producing trauma. This delay in resolution of inflammation is more common with age, and is exacerbated by an imbalance in the ratio of the omega 6 – omega 3 fats. It has been discovered that aspirin, a partial inhibitor of the COX-2 enzyme, can largely convert this enzyme to a machine that prefers acting on the omega 3 fats. Therefore, the anti-inflammatory resolvins are produced in significantly greater amounts. Consequently the tissue is more likely to return to a normal pain-free state.

It is now believed that at least part of the positive effect of aspirin on cardiovascular health is due to the production of the anti-inflammatory resolvins. Cardiovascular disease, inflammatory bowel disease, and others involve an inflammatory component, and there is now evidence that certain neurological degenerative disorders such as Alzheimer’s disease are associated with excess inflammation. The symptoms of these diseases may be attenuated by aspirin and a healthy ratio of omega 6 to omega 3.

The symptoms of these diseases may be attenuated by aspirin and a healthy ratio of omega 6 to omega 3.

So what can you do to maintain balance between inflammatory and anti-inflammatory fat-derived mediators? Eat a healthy nutritious diet, and try to hold the consumption of meats and vegetable oils (use olive oil when possible) to a minimum. Eat fish 2-3 times/week. It is recommended to consume about 1-2 grams/day of the omega 3 fats. If fish is not your dish, supplements are available. In supplement form, omega 3 is typically labeled for its two main components, DHA (docosohexaenoic acid) and EPA (eicosapentaenoic acid). For relief of pain such as that associated with arthritis, you might want to try ½ aspirin (160mg) along with an extra dose of the supplement of DHA/EPA before bed time, but be sure first to consult with your physician.


I take 2 Juvenon tablets every day.  I just noticed that my multivitamin has more biotin than Juvenon has (300mcg vs. 200mcg for 2 tablets).  Does this mess up the ratio of biotin to ALA? If so, should I take additional ALA tabs to make up for this?
T.W., via email

Benjamin V. Treadwell, Ph.D. is a member of Juvenon’s Scientific Advisory Board and formerly an associate professor at Harvard Medical School.

Send your questions to AskBen@juvenon.com.

Answers to other questions are available athttp://juvenon.com/product/qa.htm.


That amount of biotin is perfectly okay to take.

Lipoic acid, one of the components in the Juvenon™ Cellular Health Supplement, shares some structural similarity with biotin. The consequence of this structural similarity is that an increased level of one component, such as lipoic acid, can interfere with the action of the other, biotin. For the vast majority of people, the amount of biotin in Juvenon should be enough to offset this imbalance. However, it is now known that people do have genetic differences with respect to the requirement for biotin, and some (a small percentage) may be negatively effected by a competing compound, like lipoic acid. Therefore, since biotin is a safe B-vitamin, it is recommended that those people take a biotin supplement (1-5 mg/day) when taking supplements that contain lipoic acid.

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